I have used it with LR3IGF-1 alone, but not before a show. IGF1 and insulin together have a pro-insulin effect on your blood sugar balance. It can enhance the chances of a hypoglycemic episode ten fold. This is why when I am on a pre-contest diet, I am already feeling dehydrated and worn out and susceptible to an hypoglycemic episode anyway without the use of insulin. I have even tried lasix before a contest aslo, which I wouldn't recommend, as it also makes you very weak and many BB'ers have passed out on stage due to using these products, whether they did it the "correct way" or not. Sorry, just never wanted to take the chance before a contest. There are guys out there that do with good success. I just think my body couldn't handle it while on a serious diet.