I came across an interesting site online that discusses the relationship between Vitamin A and protein/testosterone. According to the article, protein is required by the body for Vitamin A transport and processing, and that excess protein consumption can lead to Vitamin A deficiency. While searching this forum, I have often come across posts in which post-Accutane patients report that consuming a greater relative amount of protein in their diets seems to improve their conditions. This relationship between protein consumption, greater Vitamin A metabolism and an easing of long-term side-effects would tend to support the theory that retinoid build-up is the cause of long-term effects from Accutane.
The article also discusses the role of Vitamin A in testosterone synthesis. Apparently, experiments have found that greater concentrations of Vitamin A in the testes increase basal testosterone secretion. Perhaps excess testosterone secretion during Accutane therapy leads to glandular exhaustion. Another possibility is that testosterone levels are unaffected, but the body's ability to convert the hormone to the more physiologically available DHT is somehow impaired via a different mechanism.
Finally, I began a previous thread on the relationship of Accutane to anabolic steroids, and according to the article, administration of Vitamin A has resulted in physiological activity that resembles the administration of testosterone itself. Anabolic steroids are nothing more than testosterone and/or testosterone precursors. Thus, if anyone felt as if they were taking anabolic steroids either during or after Accutane therapy, then it was not their imagination.