[The pharmacokinetics of Oral-Turinabol in humans]

[Article in German]

Schumann W.

Institut fur Mikrobiologie und experimentelle Therapie (ZIMET), Jena.

Disposition and excretion of the anabolic steroid Oral-Turinabol (1;4-chloro-17 alpha-methyl-androsta-1,4-diene-17 beta-hydroxy-3-one) were investigated in male volunteers. Following single p.o. and i.v. administration of the tritium-labelled compound the plasma concentration courses of total radioactivity (1 and 1-metabolites) and of the unchanged parent drug as well as the urinary excretion were estimated. From these data model independent pharmacokinetic parameters based on statistical moments were calculated. 1 is almost completely absorbed after p.o. administration of 10 mg per volunteer. Peak concentrations of total radioactivity and of 1 in plasma were reached about 3 h p.a. Irregularities observed in the plasma level profile following both p.o. and i.v. administration of 1 are due to a marked enterohepatic circulation. Orally given 1 is subject to a first-pass effect, resulting in a diminished systematic availability. The AUC-ratio of the unchanged drug and the total radioactivity of 1 : 13 shows the predominance of metabolites in plasma. After i.v. administration the disposition of unchanged 1 was found biphasically with a terminal half-life of 16 h. 1 and its metabolites are preferentially excreted via the kidneys. The urinary total radioactivity represented about 60% of the dose following both administrations. Due to its affinity to SHBG 1 is able to compete for the protein binding of testosterone, resulting in an increased plasma level of non protein-bound testosterone.

PMID: 1798729 [PubMed - indexed for MEDLINE]

Its a quicker compound than I thought it was.
NTG

I don't mean to sound dumb but I really don't understand these findings cause I am not that familiar with all the terms that they used. Could you please summarize this in lamens terms, please?? Thanks. Peace.

"with a terminal half-life of 16 h" means its biological half life is relatively short once it hits the blood stream.
"The urinary total radioactivity represented about 60% of the dose following both administrations." possibly saying high water intake could flush this compound out of the system quicker.

I think this is descent info if you were trying to figure out length of time for clearing youre system for a test or comp if you were worried about being tested.
NTG

I don't agree with the water flushing it out... what it is saying is the unchanged drug (1) and its metabolites are mainly in the blood . Orally the drug was diminished but didn't give a %... Stated IV with a 16hr 1/2 life then 60% is flushed out through the kidneys and part of it is bound to SHBG but it doesnt give a % for that...

Well I suppose drinkin more water could flush it through but it looks like it's mostly the metabolites anyway meaning the drug was used...

Thanks for breaking that down a little for me guys, cause i have the hardest time making any sense out of clinical data....lol. Guess i should have went to college!!